Panarum

Technology

Our patented technology Proteoral®

Proteoral® is the recombinant protein that delivers therapeutic proteins in the bloodstream by oral route of administration:

It is the universal oral excipient that safely transports active therapeutic protein in gastroprotectants capsules in the bloodstream.
Therapeutic polypeptides and Proteoral pass through stomach fluids in gastroprotectants capsules hermetically sealed.
In the small intestine, Proteoral® and the active therapeutic protein are released colocally.
Proteoral® opens the intercellular junctions of the intestinal epithelium and carries out the innocuous paracellular transepithelial passage of the active therapeutic proteins.
The absolute bioavailability of the active therapeutic protein successfully absorbed and distributed into the bloodstream with Proteoral is greater than 75%.
The absorbed therapeutic protein carries out its biological activity at the site of action.

PROTEORAL® IS COMBINED WITH DIFFERENT MOLECULES

In our preclinical studies with Proteoral, the absolute bioavailability of gonadotrophins absorbed into the bloodstream is consistently greater than or equal to 75% of the administered gonadotrophin dose and retains its therapeutic activity..

BENEFITS OF TAKING THERAPEUTIC PROTEINS WITH PROTEORAL®

Easy to Take
Oral Therapeutic Proteins are fully absorbed in the bloodstream.
Successful oral therapies with greater patient adherence.
Patent protected technology.
Sales increased.
Lower manufacturing costs.
Eco-Friendly Business.

PROTEORAL ACTION

Proteoral® and the therapeutic protein encapsulated in gastroprotectants pills, pass through the stomach and are released colocally in the small intestine. There, Proteoral® safely opens the intercellular junctions of the intestinal epithelium and transports the active therapeutic proteins in the bloodstream. Therapeutic proteins are distributed in their site of action and carry out their therapeutic activity..

Applications

PROTEORAL® AND ITS THERAPEUTIC AREAS

Proteoral® transports different proteins:

Oral gonadotropins in fertility therapies.
Oral insulin in insulin-dependent diabetes therapy.
Monoclonal antibodies and other oral proteins.

STRATEGIC ALLIANCE AGREEMENTS

Thanks to Proteoral® and our strategic alliance agreements with world leaders in the biopharmaceutical industry and technology investors, oral therapeutic proteins are manufactured and commercialized worldwide on a large scale with the highest standards of excellence and quality. In our agreements, we are totally successful throughout our value chain.